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Methods of surface modification of biomedical metal materials

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20 Feb,2021

Methods of surface modification of biomedical metal materials:

Biomedical chemical method for surface modification of metal materials is a new kind of technology developed in recent years. This is based on the idea that bioactive substances are directly attached to the modified metal substrate, and organic macromolecular substances such as proteins or enzymes are introduced into the substrate surface to make it have better biological activity, so it has the characteristics of more direct and more effective.

Methods of surface modification

Some researchers have treated metal surfaces with NH3 and N2 plasma to introduce amino groups, which are then quaternized by methane iodide reaction. Heparin, an anticoagulant with a negative charge sulfate, is then used to form a complex with the quaternized amino groups on the surface, thus fixing heparin on the metal surface. The nitrogen group formed on the metal surface can also be used to fix proteins. Most metal materials are coated with a hydrophilic polymer film. Under certain conditions, it will interact with [H] or H- to form hydroxyl groups (-OH) adhering to the surface of the matrix. In this case, the matrix is silylated with APS(An1Inopropyltriethox-YSI-Lane) plasma. Some proteins or enzymes, such as trypsin, are bonded to the surface of the matrix by the action of glutarate aldehyde.

This method can fix living biomolecules on the surface of metallic, inorganic, non-porous and non-loose biomaterials, thus greatly improving the surface activity of the materials. Most metal substrates, such as Ti, Ti6Al4V, Co-Cr-Mo and TiTA30, can be modified by plasma grafting of organic matter to adsorb biomolecules directly on the surface. Artificial biomaterials used for transplantation, tissue culture or other purposes must be biocompatible with the biological environment in which they are used. At present, the development needs the biocompatibility of the adherent cell surface, focused on the fixed ECM proteins and metal substrate surface, for those who don't need to attach to cells, such as blood cells used in material surface modification technology is to produce highly inert surface, such as hydrocarbons, fluoride or bioactive molecules to ban cell fixation, or producing highly hydrophilic groups, etc.

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