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Application of low-temperature plasma surface treatment equipment in cardiovascular stents and intraocular lenses

Application of low-temperature plasma surface treatment equipment in cardiovascular stents and intraocular lenses

Application of low-temperature plasma surface treatment equipment in cardiovascular stents and intraocular lenses: The urinary catheters and infusion sets in interventional instruments with low-temperature plasma surface treatment equipment have been introduced before. The biocompatibility and material bonding performance have been greatly improved, which can effectively reduce the actual clinical application of interventional instruments. The accident rate in the application. Therefore, what is the use of low-temperature plasma surface treatment equipment technology in implantable medical devices? This article mainly introduces two typical cardiovascular stents and intraocular lens devices. The processing technology of the low-temperature plasma surface treatment equipment improves the uniformity and durability of the cardiovascular stent drug coating: Almost all implantable biomaterials and related devices can be directly used in the human body, so they must have biocompatibility, such as cardiovascular stents and other materials that directly contact the blood must also have blood compatibility, so they will be used in the cardiovascular system. The surface of the stent is coated with a drug coating. The use of low-temperature plasma surface treatment technology can improve the bonding ability between the stent and the film. The main method is to use low-temperature plasma surface treatment technology to perform plasma treatment on the stent, which can improve the wettability of the stent surface and increase the adhesion. Make the medicinal film more uniform and firm. The treatment technology of the low-temperature plasma surface treatment equipment improves the hydrophilicity of the intraocular lens and effectively solves the postoperative inflammation problem: PAM intraocular lens is a new type of soft material with good diopter and flexibility, and its surface is highly viscous, can produce strong adhesion to the posterior capsule, and can effectively promote the migration and proliferation of lens epithelial cells. Reduce the occurrence of posterior capsule turbidity. However, the PAM material is highly hydrophobic and easily adsorbs bacteria and cells, resulting in postoperative inflammation. In order to improve the reliability of the intraocular lens and prevent inflammation, all current low-temperature plasma surface treatment equipment adopts the low-temperature plasma surface treatment process, and the corresponding process modification is used to increase its surface energy and improve its infiltration performance. Chengfeng Zhizao uses low-temperature plasma surface treatment technology to actively cooperate with customers to carry out research on the surface modification of medical polymer materials and surface film synthesis to solve the problem of anticoagulant, biocompatibility, surface hydrophilicity, anti-calcification and Key technical issues such as cell growth and inhibition. If you want to know more about the low-temperature plasma surface treatment equipment, or have questions about the use of the equipment, please click Chengfeng Zhizao online customer service, Chengfeng Zhizao is waiting for your call!

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The application of plasma generator in the treatment of adhesion and proliferation of PEGDA-based gel surface

The application of plasma generator in the treatment of adhesion and proliferation of PEGDA-based gel surface

The application of plasma generator in the treatment of adhesion and proliferation of PEGDA-based gel surface: The adhesion of target cells to biological materials is a prerequisite for the construction of tissue-engineered organs. Materials with good cell compatibility provide a good extracellular growth environment for cells, and maintain the normal phenotype and physiological functions of cells, and realize the restoration of tissue or organ structure and function. Polyethylene glycol (PEG) is a non-degradable polymer biomaterial approved by the US FDA. It has hydrophilicity, biocompatibility, and inhibits protein adsorption and cell adhesion. Low-molecular-weight PEG can be swallowed by phagocytes or excreted through the kidney membrane. Although the surface of the PEG-loaded material has good biocompatibility, it is difficult for cells to adhere to the surface of the material due to its resistance to proteins and cells. And growth. Therefore, the PEG substrate is activated and modified by introducing active groups, so that it can be used to construct desired biological functional materials. The chemical functional groups on the surface of biological materials (such as hydroxyl, amine, carboxyl, carbonyl, amide, etc.) have an important impact on cell compatibility and affect the hydrophilicity and hydrophobicity of the material. The hydroxy Z methacrylate monomer with active hydroxyl groups was introduced into the polyethylene glycol diacrylate substrate. The research results show that the hydroxyl groups are beneficial to cell adhesion and spreading, thereby improving the cells of PEGDA-based gel materials. Affinity; On the other hand, the surface energy of the material has an important effect on cell compatibility. It is generally believed that higher surface energy is beneficial to cell adhesion, spreading and proliferation. The use of plasma generator glow discharge surface modification technology can improve some Polar oxygen-containing and nitrogen-containing groups (such as amino and amide groups) are introduced into the surface of chemically inert materials to improve their biocompatibility. The surface roughness of the material after plasma treatment by the plasma generator is increased, and the increased surface can enhance the cell affinity of the material. After the material is plasma treated, due to the action of free radicals, electrons and ions in the plasma, the chemical bonds on the surface of the material are broken to form new chemical bonds, and the distribution of electrons near the elements also changes. The interaction between cells and matrix materials is the main field of tissue engineering research. Among them, the adhesion of cells and materials is the basis. Cells must properly adhere to the materials in order to migrate, proliferate and differentiate. The surface roughness and hydrophobicity of the materials are related to The surface energy of materials is closely related, which affects cell adhesion and proliferation. After the plasma surface treatment by the plasma generator, the surface of the membrane material is rougher than that before treatment, with uneven, undulating height, which can increase the surface area of ​​the contact between the cells and the material, and at the same time facilitate the extension of the filopodia at the cell protrusions. The filopodia are beneficial to the adhesion and spreading of cells on the surface of the material. After the material is treated with plasma, the hydrophilicity and surface energy of the material are greatly enhanced, which promotes the wetting effect of the cells on the surface of the material, and the rough surface improves the adhesion of the cells. The material modified by the plasma generator ion surface showed better cell proliferation than the unmodified membrane surface, and the cell adhesion rate was increased. The proliferation of the material after plasma treatment was generally more active than that before the treatment, and the plasma treatment condensed The film material is more conducive to the proliferation and growth of BMS on the material. Plasma-treated materials have stronger cell adaptability than untreated materials, have a higher adhesion rate, vigorous proliferation in vitro, stable growth characteristics, and form a network structure.

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Vacuum plasma equipment is the best choice to improve the reliability of copper lead frame bonding and packaging

Vacuum plasma equipment is the best choice to improve the reliability of copper lead frame bonding and packaging

Vacuum plasma equipment is the best choice to improve the reliability of copper lead frame bonding and packaging: Copper wire frame is a commonly used material in microelectronics packaging. Vacuum plasma equipment is often used in the industry to remove oxides and organics on the surface, improve the reliability of wire bonding, and increase product yield. Then the improvement effect of vacuum plasma equipment is really Is it obvious? Copper alloy materials, due to their good electrical conductivity, thermal conductivity, processing properties, and low cost of use, so in the field of microelectronic packaging, the lead frame with copper alloy materials as the main material, that is, the well-known copper lead frame, in practice In the production process, layered sealing molding often occurs, resulting in poor sealing performance and chronic air leakage of the copper lead frame after sealing molding, and it also affects the quality of chip bonding and lead connection. The main reason for this problem is the presence of copper oxide and other organic pollutants on the surface of the copper wire frame, which affects the quality and reliability of the product. Can vacuum plasma equipment effectively solve this problem? Let's take a look at the comparison below. A copper lead frame of 238mm×70mm was selected, and the angle of water droplets before and after the equipment was compared to judge the processing effect on the copper lead frame. In order to obtain more accurate data, we selected 9 points to measure separately and obtain the average value. A comparison of the average processing results of a single measurement point, multiple measurement points, and multiple measurement points shows that the copper wire skeleton processed by Chengfeng Zhizhi vacuum plasma equipment can effectively remove organic matter and oxide layer, and The surface is activated and roughened to ensure the reliability of wire bonding and packaging. This conclusion has also been verified in actual production, and the yield of the product has also been improved. Chengfeng Zhizhi has focused on the research and development of plasma cleaning machines for 20 years. If you want to know more product details or have questions about the use of the equipment, please click on Chengfeng Zhizhi online customer service, waiting for your call!

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Medical low-temperature plasma equipment needs to be wary of the electric field biological effect plasma gas temperature

Medical low-temperature plasma equipment needs to be wary of the electric field biological effect plasma gas temperature

Medical low-temperature plasma equipment needs to be wary of the electric field biological effect plasma gas temperature: Clinical plasma medicine involves a very complex biological and chemical basis. Whether it is for clinical applications or surface applications of non-clinical plasma cleaning equipment, the transmembrane potential of the electric field in the plasma of the low-temperature plasma equipment and the temperature of the plasma gas have a non-negligible effect, so let Cheng Fengzhi and you briefly analyze it. Transmembrane potential of plasma discharge electric field of low-temperature plasma equipment: When the organism is in direct contact with the plasma discharge zone, the biological effect of the electric field needs to be considered. Take the pulseless electric field as an example. Relatively speaking, the average electric field intensity in the plasma is relatively low, especially the voltage applied to the biological material is much smaller than the voltage in the plasma region. Therefore, it is usually not enough to significantly damage the cell structure. . At the same time, the conductivity of the cytoplasm and intercellular substance is one million times higher than that of the cell membrane, so current can only pass through the intercellular substance, and the cell membrane will form a barrier outside the cell to limit the pressure drop in the cytoplasm. But when an electric current passes outside the cell, the voltage flowing along the outer surface of the cell will form a gradient, resulting in a transmembrane potential. When the transmembrane potential is greater than a certain value, the cell structure will be destroyed. Since the amplitude of the transmembrane potential depends on the size, shape and direction of the cell, the destructive ability of different cells is different. Plasma temperature of low-temperature plasma equipment: The plasma used in general medicine generally refers to low-temperature plasma. Its gas temperature generally does not exceed 60°C. The temperature is slightly higher than body temperature. It will not cause burns. It can increase blood circulation, relax pores, and can treat certain diseases. It plays a role in auxiliary treatment. However, if the plasma is not uniform, it is very likely to cause the temperature in the local area to rise, which will cause local burns. The plasma uniformity is a problem that should be paid attention to in clinical medical applications. In addition, when the plasma temperature is 6°C higher than the normal temperature, that is, it exceeds 43°C, the kinetic energy of cell membrane molecules may exceed the hydration energy, leading to supramolecular polymerization and structural degeneration. Therefore, the kinetic energy damage of the cell membrane under high temperature determines the speed of cell necrosis. In short, the biological and chemical basis involved in clinical plasma medicine is very complicated. In addition to the aforementioned factors such as ultraviolet rays, charged particles, transmembrane potential, and temperature, in actual clinical applications, comprehensive consideration and careful use are required. . Chengfeng Zhizhi has focused on the research and development of low-temperature plasma equipment for 20 years. If you need to know the product details or have questions about the use of the equipment, please click on the Chengfeng Zhizhi online customer service, waiting for your call!

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The pretreatment of the plasma cleaner can significantly improve the bonding strength of the stainless steel surface coating

The pretreatment of the plasma cleaner can significantly improve the bonding strength of the stainless steel surface coating

The pretreatment of the plasma cleaner can significantly improve the bonding strength of the stainless steel surface coating: Due to its good mechanical properties, ease of processing and reliability, stainless steel is widely used in human implant materials, but due to the shortcomings of the metal itself such as thrombosis and poor corrosion resistance, the biocompatibility of stainless steel materials Not very ideal. A large number of clinical application results show that after the stainless steel artificial heart valve vascular stent is implanted in the human body, various degrees of thrombus and other adverse symptoms caused by thrombus appear on the surface of the material. Therefore, the research on how to improve the blood compatibility and histocompatibility on the surface of stainless steel materials is quite active. Among them, the method of introducing inorganic polymer materials or drugs with therapeutic effects on the surface of the materials has attracted widespread attention. In the study of various surface modification methods, the bond firmness between the coating and the substrate is an important parameter. There are many factors that affect the bonding strength between the coating and the metal substrate, such as the nature of the coating material, the chemical state and roughness of the substrate surface, the coating process, and so on. At present, most of the chemical and physical methods are used to change the chemical state or roughness of the substrate surface to improve the bonding strength between the coating and the substrate. The plasma technology process is one of the more commonly used physical treatment methods. Compared with traditional chemical methods, plasma modification belongs to a gas-solid coherent reaction system, which has the advantages of greatly improving the bonding strength between the coating and the substrate, and does not introduce other substances and does not pollute the environment. Analysis of samples after plasma treatment with a plasma cleaner revealed that the bonding strength of the surface coating of the material has been significantly improved, and the bonding strength of the surface has been enhanced. It can be seen that plasma treatment of stainless steel is an effective measure to improve the bonding strength of its surface coating. There is a layer of metal oxide and metal hydroxide on the surface of stainless steel that has been in the atmosphere for a long time. Between the metal oxide and metal hydroxide, a layer of hydrocarbon compounds is adsorbed on it. Despite a series of ultrasonic cleaning, a small amount of organic pollutants and cleaning solvents may still remain on the surface of the substrate. The surface of the sample without plasma treatment is covered with hydrocarbon compounds, and the plasma can completely remove the hydrocarbon compounds adsorbed on the surface of the stainless steel. After the plasma treatment of the plasma cleaner, the carbon hydrocarbon compounds adsorbed on the surface of the stainless steel are basically removed. The improvement of the surface cleanliness of the material is beneficial to improve the van der Waals force between the coating and the substrate. Plasma pretreatment can significantly improve the bonding strength of the stainless steel surface coating. After plasma treatment, the increase in the bonding strength of the film base is mainly related to the cleaning and etching of the surface of the base body. The increase in the bonding strength of the film substrate after plasma cleaning machine treatment is mainly due to its cleaning and activation of the substrate surface.

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Summary of the discovery and related research results of the bow single phenomenon of the micro plasma flame machine

Summary of the discovery and related research results of the bow single phenomenon of the micro plasma flame machine

Summary of the discovery and related research results of the bow single phenomenon of the micro plasma flame machine: Teschke and Kedzierski et al. published two papers in 2005, showing photos of helium-plasma jets taken with ICCD (such as enhanced charge-coupled sensors), and they discovered the phenomenon of "plasmon bow single". Since then, related research papers on the plasma bow monogram of the micro plasma flame machine have sprung up. The micro plasma flame machine is a technological process equipment that uses low-temperature plasma plasma to plasma the surface of the material. Since the discovery of plasma, there are many types of plasma research, including the plasma bow of the micro plasma flame machine. The discussion of the phenomenon. Lu and Laroussi found that the plasma bowing phenomenon has nothing to do with the specific electrode configuration. At the same time, in order to explain the plasma bowing phenomenon that occurs in the helium gas flow channel, they proposed a new photon preionization mechanism, but there are still many related problems to be solved. . Sands and others in 2008 found that the discharge of the jet area and the DBD area should be independent of each other. Through a series of specially designed experiments, Jiang et al. further confirmed this view and clearly showed that the plasma jet is essentially a corona discharge formed in the helium channel by the uneven electric field at the edge of the high-voltage electrode, although the experiment adopted The DBD structure is changed, but the jet is actually not related to DBD! To confirm this point, they showed devices with single-electrode and bare-electrode structures, which can generate completely similar plasma jets. In addition, their experiments also show that the discharge generated by a plasma jet device with a coaxial DBD structure such as Teschke should have three plasma regions. Chengfeng Zhizao has focused on the research and development of miniature plasma flame machines for 20 years. If you want to know more product details or have questions about the use of the equipment, please click on the Chengfeng Zhizao online customer service, waiting for your call!

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